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In the lab, at least, are potential rivals to orlistat in the field of lipase inhibitors; contraceptive pills names india

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US market. But, should these prototypes ever get the green light

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to go on sale, will they meet the hopes of people desperate to lose dozens of kilos in a year, rather than just a few. The three scratched drugs safe disposal prescription drugs belong to a group called cannabinoid receptor antagonists. "There are

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now just two drugs left, orlistat and sibutramine," Ricoriki Waine, a doctor who is chairman of a British organisation, the National Obesity Forum, said. Sjoedin said that researchers believed

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that regulators, especially in the United States, were becoming increasingly demanding about proposed obesity drugs. Such questions

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pose a dilemma for scientists much as they do for drug regulators. But no one is going to make a drug unless they can make money out of it in the end.". Sibutramine, sold as Reductil or Meridia, affects levels of a brain chemical called serotonin,

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believed to influence feelings of hunger or satiety. Last week, a study published in the journal BioMed Central found fenfluramine's damage to cardiac valves was visible seven years later. They come, though, with a list of side effects -- including, in orlistat's keefe,

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the risk of sudden, oily faeces. Watchdogs were wanting to see more data about adverse effects from proposed drugs, as well as further proof of benefits other than weight loss, such as lower blood pressure.

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The main causes of obesity -- overconsumption of fatty or sugary food and a sedentary lifestyle --

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are well known. As proof of the glittering allure of the obesity market, drug engineers are exploring unusual paths. In October, the European Medicines Agency (EMEA) recommended that rimonabant be pulled from sale in Europe. "Obese people will be around, and I'm not sure that surgery is the solution for all them," said Sjoedin. Obesity is a huge and growing disease, for which people are clamouring for a quick fix. Orlistat, marketed as Xenical or koral, curbs absorption of fat in the intestine by blocking a pancreatic enzyme. After investing a sum rumoured to be in the hundreds of millions of euros

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(dollars), Sanofi-Aventis of France announced last it was abandoning its drug rimonabant, which had stoked huge expectations at its launch in 2006. "The risk/benefit profile in this class of drugs was lower than expected for obtaining market And on Merck of the United States pulled the plug on its own experimental obesity fighter, taranabant, because of concerns about anxiety and depression at high doses. Eleven years ago, the search for an obesity drug ran into controversy when fenfluramine, an appetite suppressant, was banned in the United States over fears of its effect on the heart. They take on the same target in the central nervous system as marijuana. But the molecular machinery

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that drives it is in many ways obscure and, it is now suspected, more complex than thought. "In that respect, there is a need for drugs. But when it comes to that middle choice, the most promising class of new prescription medicines for treating long-term obesity has just been wiped out. Yet it is also a complex disease, and no drug is without side effects to some degree. Both are "very useful," said Waine. Massimo Sjoedin, a specialist in obesity drugs at the University of Copenhagen, Denmark, said cannabinoid receptor antagonists had now been discredited as an approach.

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Despite failures, search for anti-obesity drugs still looks golden PARIS Designers of anti-obesity drugs have suffered three major setbacks, but the potential reward from treating the world's fat epidemic is so great that their quest is unlikely to be deterred. Even more important, are they safe. Treating obesity entails a limited basket of options, from lifestyle changes to drugs and gastric-bypass surgery. But instead of sharpening appetite -- the "munchies" associated with smoking cannabis -- they work in reverse, dulling the urge to eat. "Cannabinoid receptors not only regulate the appetite, they also affect mood," he said.