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Material Safety Data Sheet
Toluene, HPLC Grade 99.8%

ACC# 89893
Section 1 - Chemical Product and Company Identification
MSDS Name: Toluene, HPLC Grade 99.8%
Catalog Numbers: AC610110040
Methacide, Methylbenzene, Methylbenzol, Phenylmethane, Toluol.
Company Identification:

       Acros Organics N.V.
       One Reagent Lane
       Fairlawn, NJ 07410
For information in North America, call: 800-ACROS-01
For information in Europe, call: 0032(0) 14575211
For emergencies in the US, call CHEMTREC: 800-424-9300
For emergencies outside the US, call: 0032(0) 14575299

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
108-88-3Toluene 99.8 203-625-9
Hazard Symbols: XN F
Risk Phrases:
11 20

Section 3 - Hazards Identification


Appearance: Clear colourless liquid. Flash Point: 4 deg C. Warning! Flammable liquid.May cause skin irritation. May be harmful if swallowed. Thissubstance has caused adverse reproductive and fetal effects inanimals. May cause central nervous system depression. Aspirationhazard. May cause cardiac disturbances. May cause liver and kidneydamage. Causes digestive and respiratory tract irritation. Causes eyeirritation and possible injury.
Target Organs: Kidneys, heart, central nervoussystem, liver.

Potential Health Effects

Eye: Causes eye irritation. May result in corneal injury. Vapors may cause eye irritation.
Skin: May cause skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
Ingestion: Aspiration hazard. May cause irritation of the digestive tract. May cause effects similar to those for inhalation exposure. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal.
Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by headache, dizziness, unconsciousness and coma. Inhalation of vapor may cause respiratory tract irritation. May cause liver and kidney damage. May cause heart disturbances, possibly leading to cardiac arrest and death.
Chronic: Chronic exposure to organic solvents has been associated with various neurotoxic effects including permanent brain and nervous system damage. Prolonged or repeated skin contact may cause dermatitis. May cause cardiac sensitization and severe heart abnormalities. May cause liver and kidney damage.

Section 4 - First Aid Measures

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid immediately.
Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Possible aspiration hazard. Get medical aid immediately.
Inhalation: Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician: Causes cardiac sensitization to endogenous catelcholamines which may lead to cardiac arrhythmias. Do NOT use adrenergic agents such as epinephrine or pseudoepinephrine.

Section 5 - Firefighting Measures

General Information: Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May be ignited by heat, sparks, and flame. Containers may explode when heated.
Extinguishing Media: Use water spray to cool fire-exposed containers. Do NOT use straight streams of water. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. For small fires, use carbon dioxide, dry chemical, dry sand, or alcohol-resistant foam. Contact professional fire-fighters immediately. Cool containers with flooding quantities of water until well after fire is out.
Autoignition Temperature: 535 deg C (995.00 deg F)
Flash Point: 4 deg C (39.20 deg F)
NFPA Rating: health-2; flammability-3; reactivity-0 Explosion Limits, Lower: 1.20 vol % Upper: 7.00 vol %

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Avoid runoff into storm sewers and ditches which lead to waterways. Use water spray to disperse the gas/vapor. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. A vapor suppressing foam may be used to reduce vapors. Use water spray to reduce vapors, do not put water directly on leak, spill area or inside container.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Use only in a well ventilated area. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Avoid contact with skin and eyes. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Toluene50 ppm ; 188 mg/m3; skin - potential for cutaneous absorption100 ppm TWA; 375 mg/m3 TWA 500 ppm IDLH200 ppm TWA; C 300 ppm; C 300 ppm

OSHA Vacated PELs: Toluene: 100 ppm TWA; 375 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - Physical and Chemical Properties

Physical State: Liquid
Appearance: Clear colourless liquid
Odor: Aromatic, sweet.
pH: Not available.
Vapor Pressure: 10 mm Hg
Vapor Density: 3.1 (Air=1)
Evaporation Rate:
Viscosity: 0.59 cP 20 deg
Boiling Point: 110.6760.00 deg C
Freezing/Melting Point:-95 deg C
Decomposition Temperature:Not available.
Solubility: 0.05 G/100ML WATER (200C)
Specific Gravity/Density:.8650g/cm3
Molecular Formula:C7H8
Molecular Weight:

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Ignition sources, excess heat, electrical sparks, exposure to flame.
Incompatibilities with Other Materials: Acids (mineral, oxidizing, e.g. chromic acid, hypochlorous acid, nitric acid, sulfuric acid), oxidizing agents (strong, e.g. bromine, hydrogen peroxide, nitrogen dioxide, potassium nitrate), water reactive substances (e.g. acetic anyhdride, alkyl aluminum chloride, calcium carbide, ethyl dichlorosilane).
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

CAS# 108-88-3: XS5250000
CAS# 108-88-3:
Inhalation, mouse: LC50 =400 ppm/24H;
Inhalation, rat: LC50 =49 gm/m3/4H;
Oral, rat: LD50 = 636 mg/kg;
Skin, rabbit: LD50 = 12124 mg/kg;
CAS# 108-88-3:
ACGIH: A4 - Not Classifiable as a Human Carcinogen
IARC: Group 3 carcinogen
Epidemiology: No data available.
Teratogenicity: No data available.
Reproductive Effects: No data available.
Neurotoxicity: No data available.
Mutagenicity: No data available.
Other Studies: None.

Section 12 - Ecological Information

Ecotoxicity: Bluegill LC50=17 mg/L/24H Shrimp LC50=4.3 ppm/96H Fathead minnow LC50=36.2 mg/L/96H Sunfish (fresh water) TLm=1180 mg/L/96H
Environmental Fate: From soil, substance evaporates and is microbially biodegraded. In water, substance volatilizes and biodegrades.
Physical/Chemical: Photochemically produced hydroxyl radicals degrade substance.
Other: None.

Section 13 - Disposal Considerations

Dispose of in a manner consistent with federal, state, and local regulations.
RCRA D-Series Maximum Concentration ofContaminants: None listed.
RCRA D-Series Chronic Toxicity ReferenceLevels: None listed.
RCRA F-Series: None listed.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 108-88-3: waste numberU220.

Section 14 - Transport Information

Shipping Name:TOLUENENo information available.No information available.No information available.No information available.
Hazard Class:3
UN Number:UN1294
Packing Group:II

Section 15 - Regulatory Information


CAS# 108-88-3 is listed on the TSCA inventory.
Health & Safety Reporting List
CAS# 108-88-3: Effective Date: October 4, 1982; Sunset Date: October 4 , 1992
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.

Section 302 (RQ)
CAS# 108-88-3: final RQ = 1000 pounds (454 kg)
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 108-88-3: acute, flammable.
Section 313
This material contains Toluene (CAS# 108-88-3, 99 8%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 108-88-3 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 108-88-3 is listed as a Hazardous Substance under the CWA. CAS# 108-88-3 is listed as a Priority Pollutant under the Clean Water Act. CAS# 108-88-3 is listed as a Toxic Pollutant under the Clean Water Act.
None of the chemicals in this product are considered highly hazardous by OSHA.
CAS# 108-88-3 can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts.
WARNING: This product contains Toluene, a chemical known to the state of California to cause birth defects or other reproductive harm. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
Risk Phrases:

R 11 Highly flammable. R 20 Harmful by inhalation.
Safety Phrases:

S 16 Keep away from sources of ignition - No smoking. S 25 Avoid contact with eyes. S 29 Do not empty into drains. S 33 Take precautionary measures against static discharges.
WGK (Water Danger/Protection)

CAS# 108-88-3: 2
CAS# 108-88-3 is listed on Canada's DSL/NDSL List.
WHMIS: Not available.
CAS# 108-88-3 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 108-88-3: OEL-AUSTRALIA:TWA 100 ppm (375 mg/m3);STEL 150 ppm (5
60 mg/m3) OEL-BELGIUM:TWA 100 ppm (377 mg/m3);STEL 150 ppm (565 mg/m3
0 ppm (190 mg/m3);Skin OEL-FINLAND:TWA 100 ppm (375 mg/m3);STEL 150 p
pm;Skin OEL-FRANCE:TWA 100 ppm (375 mg/m3);STEL 150 ppm (560 mg/m3)
OEL-GERMANY:TWA 100 ppm (380 mg/m3) OEL-HUNGARY:TWA 100 mg/m3;STEL 30
0 mg/m3;Skin OEL-JAPAN:TWA 100 ppm (380 mg/m3) OEL-THE NETHERLANDS:T
WA 100 ppm (375 mg/m3);Skin OEL-THE PHILIPPINES:TWA 100 ppm (375 mg/m
3) OEL-POLAND:TWA 100 mg/m3 OEL-RUSSIA:TWA 100 ppm;STEL 50 mg/m3 OE
L-SWEDEN:TWA 50 ppm (200 mg/m3);STEL 100 ppm (400 mg/m3);Skin OEL-SWI
TZERLAND:TWA 100 ppm (380 mg/m3);STEL 500 ppm OEL-THAILAND:TWA 200 pp
m;STEL 300 ppm OEL-TURKEY:TWA 200 ppm (750 mg/m3) OEL-UNITED KINGDOM
:TWA 100 ppm (375 mg/m3);STEL 150 ppm;Skin OEL IN BULGARIA, COLOMBIA,
check ACGI TLV

Section 16 - Additional Information

MSDS Creation Date: 2/27/1998
Revision #2 Date: 3/12/1998
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.