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Material Safety Data Sheet
Hexanes, c.p.

ACC# 98123
Section 1 - Chemical Product and Company Identification
MSDS Name: Hexanes, c.p.
Catalog Numbers: AC210590000, AC210590010, AC210590025
Synonyms:
n-Hexane; Hexyl Hydride; Dipropyl
Company Identification:

       Acros Organics N.V.
       One Reagent Lane
       Fairlawn, NJ 07410
For information in North America, call: 800-ACROS-01
For information in Europe, call: 0032(0) 14575211
For emergencies in the US, call CHEMTREC: 800-424-9300
For emergencies outside the US, call: 0032(0) 14575299

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
110-54-3Hexanes 100.0 203-777-6
Hazard Symbols: XN F
Risk Phrases:
11 48/20

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: clear, colorless. Flash Point: -22 deg C. Danger! Extremely flammableliquid. May cause respiratory tract irritation. Causesskin irritation. Air sensitive. May cause central nervous systemdepression. Aspiration hazard. May cause reproductive effects basedupon animal studies. Causes severe eye irritation. May causedigestive tract irritation with nausea, vomiting, and diarrhea.
Target Organs: Central nervous system.

Potential Health Effects

Eye: Causes severe eye irritation.
Skin: Causes skin irritation. Causes irritation with burning pain, itching, and redness. May cause blistering of the skin.
Ingestion: Aspiration hazard. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. May cause central nervous system effects.
Inhalation: Causes respiratory tract irritation. May cause severe irritation of the upper respiratory tract with pain, burns, and inflammation. Exposure produces central nervous system depression. Aspiration may cause respiratory swelling and pneumonitis. Vapors may cause dizziness or suffocation.
Chronic: May cause reproductive and fetal effects. Chronic exposure produces peripheral neuropathy.

Section 4 - First Aid Measures


Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid immediately.
Skin: Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. Allow the victim to rinse his mouth and then to drink 2-4 cupfuls of water, and seek medical advice.
Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Firefighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Extremely flammable liquid. Containers may explode in the heat of a fire. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media: Use water spray to cool fire-exposed containers. In case of fire, use water fog, dry chemical, carbon dioxide, or regular foam. Do NOT use straight streams of water. Contact professional fire-fighters immediately.
Autoignition Temperature: 225 deg C (437.00 deg F)
Flash Point: -22 deg C (32.00 deg F)
NFPA Rating: health-1; flammability-3; reactivity-0 Explosion Limits, Lower: 1.10 vol % Upper: 7.50 vol %

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Remove all sources of ignition. A vapor suppressing foam may be used to reduce vapors.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Use only in a well ventilated area. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Take precautionary measures against static discharges. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Hexanes(50) ppm ; (176) mg/m350 ppm TWA; 180 mg/m3 TWA 1100 ppm IDLH (10 percent lower explosive limit)500 ppm TWA; 1800 mg/m3 TWA

OSHA Vacated PELs: Hexanes: 50 ppm TWA; 180 mg/m3 TWA
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - Physical and Chemical Properties


Physical State: Liquid
Appearance: clear, colorless
Odor: gasoline-like
pH: Not available.
Vapor Pressure: 150 mm Hg @24.8C
Vapor Density: 3.0 (air=1)
Evaporation Rate:
Viscosity: 0.31 mPas 20 de
Boiling Point: 156 deg F
Freezing/Melting Point:-95 deg C
Decomposition Temperature:Not available.
Solubility: Insoluble.
Specific Gravity/Density:0.7
Molecular Formula:C6H14
Molecular Weight:

Section 10 - Stability and Reactivity


Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Ignition sources, exposure to air, excess heat, electrical sparks.
Incompatibilities with Other Materials: Strong oxidizing agents, coatings, plastics, rubber.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - Toxicological Information


RTECS#:
CAS# 110-54-3: MN9275000
LD50/LC50:
CAS# 110-54-3:
Oral, rat: LD50 = 28710 mg/kg;
Carcinogenicity:
CAS# 110-54-3: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: Carcinogenicity:Calculated mean lifetime cancer risk in huma ns from indoor pollution levels of 1.8-51.0 5g/m3 was negl igible.
Teratogenicity: Effects on Newborn: reduced weight gain, ihl-rat TCLo=1000 ppm/6H.Embryo or Fetus: Stunted fetus, ihl-rat TCLo=5000 ppm/20H.Inhalation pregnant rat and offspring 500, 800, 1000, 1500 ppm, 23 hr/day showed concentration dependant intrauterine mortality. Offspring exposed prenatally only showed reduced body growth at all concentrations and delayed cerebellar cortex maturation. In pre- and post-exposure cases, effects of malnutrition added to the solvent-induced retardation causing delayed tissue maturation and cell maturation.Neurotoxicity was restricted to axonal damage in adults.
Reproductive Effects: ihl-rat TCLo: 10000ppm/7H (15D pre-mating)ihl-rat TCLo: 1000 ppm/6H (8-16D preg)ihl-rat TCLo: 5000 ppm/20H (6-19D preg)orl-mus TDLo: 238 gm/kg (6-15D preg)Paternal Effects: Testes/sperm duct/epididymis,ihl-rat TCLo=1 pph/6H.Inhalation rat 5000 ppm for <6 wk caused testicular damage. The earliest lesions were observed after 24 hr continuous treatment which involved primary spermatocytes and spermatids, while numerous exfoliated injured germ cells reached the epididymus. After interruption, testicular lesions became increasingly severe suggesting an irreversible sterility.
Neurotoxicity: Of 56 offset printing workers exposed to n-Hexane, 20 develo ped symptomatic peripheral neuropathy and 26 had sub-c linical neuropathy. Development of neuropathy bore no relati onship to the duration of exposure.Calculated whole body dermal permeability constants for humans were two to four times less than experimental permeability constants for rats exposed to 60,000 ppm probably due to physiological differences in skin.
Mutagenicity: cyt-ham: fbr 500 mg/lsln-smc: 132 mmol/lSalmonella typhimurium TA98, TA100 with and without metabolic activation negative.
Other Studies: None.

Section 12 - Ecological Information


Ecotoxicity: Fish toxicity:LC50 (24 hr) goldfish 4 mg/lLC5, LC50, LC95 cichlid 40-185.5 ppm at pH 7.1 and 27.80C (duration unspecified).Exposed fish showed gill damage, respiratory distress and loss of balance.Invertebrate toxicity:LC50 Branchiura sowerbyi 3290 ppm at pH 7.1 and 27.80C (duration unspecified).LC50 (96 hr) Chlorella vulgaris 1097 mg/l.
Environmental Fate: Substance readily volatilizes when released on soil or to water (with minor absorption to soil or sediment). The potential for aquatic bioconcentration is low. In air, substance is predicted to exist in vapor phase and will react with photochemically produced hydroxyl radicals.Degradation studies:Hydroxylated and oxidised to the corresponding alcohol, aldehyde, acid and ketone mixture by methane oxidising bacterium H-2 (type I).ThOD 3.52 mg/l O2.
Physical/Chemical: No information available.
Other: Degradation studies:Incubation with natural flora in groundwater in presence of other components of high octane gasoline (100 5l/l), biodegraded by 46% after 192 hr at 130C, initial concentration 1.36 5l/l.Catabolically degraded by gasoline-degrading bacteria Pseudomonas sp., Nocardia sp. and Micrococcus sp.Abiotic removal:Photooxidation by UV light in aqueous medium at 500C, 50.51% degraded to carbon dioxide after 24 hr.

Section 13 - Disposal Considerations

Dispose of in a manner consistent with federal, state, and local regulations.
RCRA D-Series Maximum Concentration ofContaminants: None listed.
RCRA D-Series Chronic Toxicity ReferenceLevels: None listed.
RCRA F-Series: None listed.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT IATA RID/ADR IMO Canada TDG
Shipping Name:HEXANESHEXANESHEXANESHEXANESNo information available.
Hazard Class:333(3B)3.1
UN Number:UN1208UN1208UN1208UN1208
Packing Group:IIIIII

Section 15 - Regulatory Information

US FEDERAL

TSCA
CAS# 110-54-3 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA

Section 302 (RQ)
None of the chemicals in this material have an RQ.
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 110-54-3: acute, chronic, flammable, sudden release of pressure.
Section 313
This material contains Hexanes (CAS# 110-54-3, 100 0%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
CAS# 110-54-3 is listed as a hazardous air pollutant (HAP). This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 110-54-3 can be found on the following state right to know lists: New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN F
Risk Phrases:

R 11 Highly flammable. R 48/20 Harmful : danger of serious damage to health by prolonged exposure through inhalation.
Safety Phrases:

S 16 Keep away from sources of ignition - No smoking. S 24/25 Avoid contact with skin and eyes. S 29 Do not empty into drains. S 51 Use only in well ventilated areas. S 9 Keep container in a well-ventilated place.
WGK (Water Danger/Protection)

CAS# 110-54-3: 1
Canada
CAS# 110-54-3 is listed on Canada's DSL/NDSL List.
WHMIS: Not available.
CAS# 110-54-3 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 110-54-3: OEL-AUSTRALIA:TWA 50 ppm (180 mg/m3) OEL-BELGIUM:TWA
50 ppm (176 mg/m3) OEL-DENMARK:TWA 50 ppm (180 mg/m3) OEL-FINLAND:T
WA 50 ppm (180 mg/m3);STEL 150 ppm (530 mg/m3) OEL-FRANCE:TWA 50 ppm
(170 mg/m3) OEL-GERMANY:TWA 50 ppm (180 mg/m3) OEL-HUNGARY:TWA 100 m
g/m3;STEL 200 mg/m3;Skin OEL-JAPAN:TWA 40 ppm (140 mg/m3);Skin OEL-T
HE NETHERLANDS:TWA 100 ppm (360 mg/m3) OEL-THE PHILIPPINES:TWA 500 pp
m (1800 mg/m3) JAN9 OEL-POLAND:TWA 400 mg/m3 OEL-RUSSIA:TWA 40 ppm;S
TEL 300 mg/m3 OEL-SWEDEN:TWA 25 ppm (90 mg/m3);STEL 50 ppm (180 mg/m3
) OEL-SWITZERLAND:TWA 50 ppm (180 mg/m3);STEL 100 ppm (360 mg/m3) OE
L-TURKEY:TWA 500 ppm (1800 mg/m3) OEL-UNITED KINGDOM:TWA 100 ppm (360
mg/m3);STEL 125 ppm OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check A
CGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV

Section 16 - Additional Information

MSDS Creation Date: 11/19/1996
Revision #3 Date: 10/20/1997
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.